Primary hyperaldosteronism in normokaliemic patients with adrenal incidentalomas

Adrenal Venous Sampling in Primary Hyperaldosteronism

Adrenal venous sampling (AVS) is used to distinguish unilateral from bilateral aldosterone hypersecretion as a cause of primary hyperaldosteronism (PHA). This distinction is critical because unilateral disease is treated, and often cured, by adrenalectomy, whereas bilateral hypersecretion should be managed medically. In this article, we review the epidemiology and etiologies of PHA, present scr...

[Primary hyperaldosteronism due to adrenal adenoma].

Giant adrenal adenoma with hyperaldosteronism.

1. Adrenal tumor. (A) Abdominal computed tomography showed a large mass with smooth margin, 6.0 cm in diameter, in the left adrenal gland. No sweling of the lymph nodes around the tumor was observed. (B) An adenoma measuring 7.5×6.0×5.5 cm and weighing 122 g with a smooth surface was removed. Its cut surface was golden yelow. (C) HE stain ×20. The adenoma was encapsulated. The adjacent normal a...

Utility of F-18 FDG-PET in Detecting Primary Aldosteronism in Patients with Bilateral Adrenal Incidentalomas

In patients with primary aldosteronism who have bilateral adrenal incidentalomas, it is important to identify which adrenal gland is secreting excess aldosterone. Traditionally, adrenal vein sampling (AVS) has been performed for lateralization despite its invasiveness. Here we report a case of bilateral adrenal incidentaloma in which 18-Fluorodeoxyglucose (FDG)-positron emission tomography (PET...

Angiotensin II receptor subtypes on adrenal adenoma in primary hyperaldosteronism.

Patients with an aldosterone-producing adenoma (APA) characteristically fail to show an increase in plasma aldosterone (PA) concentration with maneuvers that increase angiotensin II (Ang II), yet they retain a brisk response of PA to adrenocorticotrophic hormone. Therefore, adrenal Ang II receptor binding was characterized in a patient with APA who had a blocked PA response to Ang II infusion b...